SOR-C13 peptide

SOR-C13 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KEFLHPSKVDLPR-OH

H-Lys-Glu-Phe-Leu-His-Pro-Ser-Lys-Val-Asp-Leu-Pro-Arg-OH

13

95.15%

C₇₂H₁₁₆N₂₀O₁₉

1565.81

Synthetic

Powder

SOR-C13 is a carboxy terminal truncated peptide derived from the 54 residue paralytic peptide soricidin, found in the paralytic venom of the short-tailed shrew Blarina brevicauda. SOR-C13 is a high affinity, use dependent antagonist of human transient receptor potential vanilloid 6 (TRPV6) channels with an IC50 of 14 nM. TRPV6 is a non-voltage gated calcium channel implicated in malignancies and poor prognosis in breast cancer. In vivo, SOR-C13 reduces the growth of human ovarian xenografts in NOD/SCID mouse models.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Bowen et al (2013) In vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin. PLoS One 8(3) e58866 PMID: 23554944
• Xue et al (2018) Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model. J Cancer 9(17) 3196 PMID: 30210643

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.