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  • Smac-N7 Peptide

Smac-N7 Peptide

Not For Human Use, Lab Use Only.

Cat.#: 308770

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Product Information

  • Product Name
    Smac-N7 Peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    AVPIAQK
  • Sequence
    H-Ala-Val-Pro-Ile-Ala-Gln-Lys-OH
  • Length (aa)
    7
  • Peptide Purity (HPLC)
    99.96%
  • Molecular Formula
    C33H59N9O9
  • Molecular Weight
    725.88
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Smac-N7 Peptide corresponds to the N-terminal seven residues of Smac (second mitochondria-derived activator of caspase) also known as DIABLO. Smac/DIABLO is a mitochondrial proapoptotic protein that activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway by neutralizing inhibitor of apoptosis protein (IAP).Smac-N7 peptide promoted procaspase-3 activation in vitro at around 10 uM and inhibited binding of caspase-9-p12 to the BIR3 (baculoviral IAP repeat 3) domain of XIAP (X-linked IA
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • C.Du et al., Cell, 102, 33 (2000)
    • S.M.Srinivasula et al., J. Biol. Chem., 275, 36152 (2000)
    • J.Chai et al., Nature, 406, 855 (2000)
    • S.M.Srinivasula et al., Nature, 401, 112 (2001)
    • T.E.Fandy et al., Mol. Cancer, 7, 60 (2008)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-AVPIAQK-OH
  • Chemical Formula:C33H59N9O9
  • Sequence length:7
  • Extinction coefficient:0 M-1cm-1
  • GRAVY:0.47
  • Mw average:725.87
  • Theoretical pI:10.09
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"