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Product Name
Recombinant SLIRP protein (His tag)
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Description
Introducing the recombinant SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) fragment (residues 1-109), a high-purity tool designed for studying RNA-binding mechanisms and nuclear receptor corepressor functions. This fragment fully encompasses the RRM domain, making it ideal for targeted investigations into SLIRP's molecular interactions.
The full-length SLIRP protein, encoded by the SLIRP gene in Homo sapiens, functions as an RNA-binding protein and nuclear receptor corepressor. It binds specifically to the SRA RNA, repressing SRA-mediated coactivation of nuclear receptors, and has been shown to inhibit transactivation by glucocorticoid (GR), androgen (AR), thyroid (TR), and vitamin D (VDR) receptors. SLIRP localizes predominantly to the mitochondrion, with a fraction present in the nucleus, where it is recruited to nuclear receptor target promoters, highlighting its dual role in transcriptional regulation and mitochondrial processes.
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Protein name
SRA stem-loop-interacting RNA-binding protein, mitochondrial
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Uniprot ID
Q9GZT3
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Gene Name
SLIRP; C14orf156
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-109 aa (Q9GZT3) were fused with C-terminal 6His tag.
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Sequence
MAASAARGAA ALRRSINQPV AFVRRIPWTA ASSQLKEHFA QFGHVRRCIL PFDKETGFHR GLGWVQFSSE EGLRNALQQE NHIIDGVKVQ VHTRRPKLPQ TSDDEKKDFL EHHHHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.00 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant SLIRP protein (His tag) SDS-PAGE
M: Marker; Lane 1: SLIRP; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"