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  • SLAY-P2 peptide

SLAY-P2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 318837

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* Buy 1 get 1 free (?) What is TFA?

Special Price 173.10 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    SLAY-P2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-TTSIRRRYQVSLIRRHRGKR-OH
  • Sequence
    H-Thr-Thr-Ser-Ile-Arg-Arg-Arg-Tyr-Gln-Val-Ser-Leu-Ile-Arg-Arg-His-Arg-Gly-Lys-Arg-OH
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95.2%
  • Molecular Formula
    C107H191N45O27
  • Molecular Weight
    2539.94
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Surface localized antimicrobial display (SLAY)-derived cationic peptides exhibit moderate bactericidal activity against Enterococcus, with minimal inhibitory concentration (MIC) values of 2-8 μg/mL. SLAY-P1 shows synergistic activity with vancomycin against vancomycin-resistant Enterococcus (VRE). SLAY-P1 specifically inhibits transcription of the vanRS two-component system, restoring vancomycin activity and causing accumulation of the cell wall precursor. The combination of SLAY-P1 and vancomycin prevents the emergence of vancomycin resistance.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Liu Y, Jia Y, Yang K, Li R, Xiao X, Wang Z. Antagonizing Vancomycin Resistance in Enterococcus by Surface Localized Antimicrobial Display-Derived Peptides. ACS Infect Dis. 2020;6(5):761-767. doi:10.1021/acsinfecdis.9b00164
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-TTSIRRRYQVSLIRRHRGKR-OH
  • Chemical Formula:C107H191N45O27
  • Sequence length:20
  • Extinction coefficient:1280 M-1cm-1
  • GRAVY:-1.49
  • Mw average:2539.94
  • Theoretical pI:12.8
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"