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  • Sincalide peptide

Sincalide peptide

Not For Human Use, Lab Use Only.

Cat.#: 319791

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* Buy 1 get 1 free (?) What is TFA?

Special Price 419.00 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Sincalide peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence
    D-{SO3H-Tyr}-MGWMDF-NH2
  • Length (aa)
    7
  • Peptide Purity (HPLC)
    95%
  • Molecular Formula
    C49H62N10O16S3
  • Molecular Weight
    1143.27
  • CAS No.
    25126-32-3
  • PubChem CID
    9833444
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Sincalide is a synthetic polypeptide hormone analog of cholecystokinin, composed of amino acids. It exhibits hepatobiliary physiological effects by stimulating bile secretion, inducing gallbladder contraction, and relaxing the sphincter of Oddi, facilitating bile drainage into the duodenum. The peptide is known for its specificity and minimal side effects, primarily nausea and abdominal cramping when administered too rapidly.

    Structurally, sincalide mimics the C-terminal octapeptide of cholecystokinin, retaining its biological activity. The peptide's mechanism involves binding to cholecystokinin receptors on gallbladder smooth muscle cells and biliary tree epithelia. Optimal activity is observed with controlled infusion rates, as rapid administration can lead to receptor desensitization and physiological artifacts. Its molecular properties make it a valuable tool for studying biliary physiology and related biological processes.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Ziessman HA. Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues. J Nucl Med Technol. 2019 Sep;47(3):210-212. doi: 10.2967/jnmt.119.226019. Epub 2019 Apr 24. PMID: 31019045.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"