sGnRH-A peptide

sGnRH-A peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Pyr-HWSYrWLP-NHEt, r=D-Arg

Pyr-His-Trp-Ser-Tyr-D-Arg-Trp-Leu-Pro-NHEt

8

95.74%

C₆₄H₈₃N₁₇O₁₂

1282.45

96497-82-4

121493629

Synthetic

Powder

sGnRH-A ([D-Arg⁶, Pro⁹]-LHRH) is a synthetic analog of gonadotropin-releasing hormone (GnRH). sGnRH-A can elevate the GH mRNA level and stimulate the GH secretion in common carp pituitary fragments in a dose-dependent manner. Compared to other GnRHs and its analogs, it shows a higher potency in increasing the GH mRNA level and GH release. In a time-course experiment, its function on GH secretion was observed after 6 h incubation, while its effect on the GH mRNA level was noted after 12 h treatment. Among mammalian GnRH, avian GnRH, and piscine GnRH, sGnRH and sGnRH-A showed the highest potency in increasing GH mRNA level and GH release, followed by cGnRH-II ([His⁵, Tyr⁸]-LHRH), and finally LHRH and LHRH-A ([D-Trp⁶, Pro⁹]-LHRH).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Li WS, Lin HR, Wong AO. Effects of gonadotropin-releasing hormone on growth hormone secretion and gene expression in common carp pituitary. Comp Biochem Physiol B Biochem Mol Biol. 2002 Jun;132(2):335-41. doi: 10.1016/s1096-4959(02)00039-8. PMID: 12031458.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.