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Product Name
Recombinant SGK2 protein (His tag)
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Description
Recombinant Human Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1), encompassing amino acids 1-367, is a high-purity fragment designed for studying kinase activity and domain-specific functions. This product includes the complete Protein kinase and AGC-kinase C-terminal domains, making it an ideal tool for investigating ion channel regulation, cellular signaling, and proliferation mechanisms.
Serine/threonine-protein kinase Sgk2 (Serum/glucocorticoid-regulated kinase 2) is a key regulatory enzyme involved in controlling diverse cellular processes. It functions by phosphorylating and modulating the activity of numerous ion channels and transporters, including sodium channels (SCNN1A/ENaC), potassium channels (KCNA3/Kv1.3, KCNE1, KCNQ1), amino acid transporters (SLC6A19), glutamate transporters (SLC1A6/EAAT4), glutamate receptors (GRIA1/GLUR1, GRIK2/GLUR6), sodium/hydrogen exchangers (SLC9A3/NHE3), and the Na+/K+ ATPase. Through these interactions, Sgk2 plays crucial roles in cell growth, survival, and proliferation pathways. The protein localizes to both the cytoplasm and nucleus, indicating potential roles in multiple cellular compartments. The recombinant fragment (1-367) preserves the essential functional domains necessary for kinase activity and substrate recognition.
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Protein name
Serine/threonine-protein kinase Sgk2
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Uniprot ID
Q9HBY8
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Gene Name
SGK2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-367 aa (Q9HBY8) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 42.83 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 43 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"