Mouse Serum amyloid P component (His Tag) recombinant protein

Cat.#: 502572

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Product Information

  • Product Name
    Mouse Serum amyloid P component (His Tag) recombinant protein
  • Documents
  • Description
    Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.
  • Protein name
    Serum amyloid P-component
  • Protein short names
    SAP; MGC88159; PTX2; APCS; HEL-S-92N
  • Uniprot ID
    Q4JFI8
  • Gene Name
    Apcs; Ptx2; Sap
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse APCS (NP_035448.2) (Met 1-Glu 224) precursor was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse APCS consists of 215 amino acids and has a calculated molecular mass of 25.3 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 28 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA. Immobilized mouse APCS at 10 μg/ml (100 μl/well) can bind biotinylated human Fibronectin Fragment 2 with a linear ranger of 0.625-5 μg/ml.
    2. Measured by its ability to bind mouse CD64-AVI in a functional ELISA.
  • Validations

    Mouse Serum amyloid P component / APCS / SAP Protein (His Tag) SDS-PAGE

    Mouse Serum amyloid P component / APCS / SAP Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"