Recombinant SENP8 protein (His tag)

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Recombinant Human Sentrin-specific protease 8 (SENP8) Fragment (1-212) is a high-purity, functionally relevant protein fragment designed for structural and biochemical studies. This product captures the essential catalytic domain of SENP8, enabling researchers to investigate its critical roles in NEDD8 processing and deconjugation with enhanced solubility and stability.

Sentrin-specific protease 8 (SENP8), also known as deneddylase-1 or NEDD8-specific protease 1, is a cysteine protease that plays a dual role in the NEDD8 pathway. It processes full-length NEDD8 to its mature form and deconjugates NEDD8 from target proteins such as cullins and p53, thereby regulating essential cellular processes including protein degradation and signaling. This fragment (residues 1-212) represents a stable, soluble unit computationally selected to facilitate mechanistic studies of SENP8's enzymatic functions without the complexities of the full-length protein.