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Recombinant SENP5 protein (His tag)

Cat.#: 545685

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Product Information

  • Product Name
    Recombinant SENP5 protein (His tag)
  • Documents
  • Description

    This product is a recombinant fragment of Sentrin-specific protease 5 (SENP5), spanning residues 493-755, derived from Homo sapiens. It represents a stable and soluble unit optimized for structural and biochemical studies, supporting research into SUMO pathway regulation and cellular division mechanisms.

    Sentrin-specific protease 5 (SENP5) is a crucial enzyme in the SUMO pathway, responsible for processing full-length SUMO3 to its mature form and deconjugating SUMO2 and SUMO3 from target proteins. While it exhibits weak activity toward SUMO1, its functions are essential for proper cell division. SENP5 is localized primarily in the nucleus and nucleolus, underscoring its role in nuclear processes. This fragment, selected for stability and solubility, enables detailed investigation of SENP5's biochemical properties without the complexities of the full-length protein.

  • Protein name
    Sentrin-specific protease 5
  • Uniprot ID
    Q96HI0
  • Gene Name
    SENP5
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 493-755 aa (Q96HI0) were fused with C-terminal 6His tag.
  • Sequence 
    MPVDDEQLSV CLSGFLDEVM KKYGSLVPLS EKEVLGRLKD VFNEDFSNRK PFINREITNY RARHQKCNFR IFYNKHMLDM
DDLATLDGQN WLNDQVINMY GELIMDAVPD KVHFFNSFFH RQLVTKGYNG VKRWTKKVDL FKKSLLLIPI HLEVHWSLIT
VTLSNRIISF YDSQGIHFKF CVENIRKYLL TEAREKNRPE FLQGWQTAVT KCIPQQKNDS DCGVFVLQYC KCLALEQPFQ
FSQEDMPRVR KRIYKELCEC RLMDLEHHHH HH
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 32.85 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 34 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant SENP5 protein (His tag) SDS-PAGE

    Recombinant SENP5 protein (His tag) SDS-PAGE

    M: Marker; Lane 1: SENP5; Lane 2: BSA

    Recombinant SENP5 protein (His tag) Western Blot

    Recombinant SENP5 protein (His tag) Western Blot

    M: Marker; Lane 1: SENP5; Lane 2: Multitag Protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"