Cart 2
  • Senktide peptide

Senktide peptide

Not For Human Use, Lab Use Only.

Cat.#: 319799

Size:

* Buy 1 get 1 free (?) What is TFA?

Special Price 240.00 USD

Availability: 1-2 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Senktide peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Suc-DF-{Me-Phe}-GLM-NH2
  • Sequence
    Suc-Asp-Phe-{Me-Phe}-Gly-Leu-Met-NH2
  • Length (aa)
    6
  • Peptide Purity (HPLC)
    95%
  • Molecular Formula
    C40H55N7O11S
  • Molecular Weight
    841.97
  • CAS No.
    106128-89-6
  • PubChem CID
    108147
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Senktide is a selective tachykinin NK3 receptor agonist, characterized by its ability to induce hyperlocomotion in male Mongolian gerbils upon intracerebroventricular injection. This peptide exhibits dose-dependent effects, with significant locomotor activity observed at doses ranging from 0.06 nmol to 0.6 nmol. The hyperlocomotion induced by senktide is mediated through tachykinin NK3 receptor activation, as demonstrated by its blockade with specific NK3 receptor antagonists such as SB222200, talnetant, and osanetant.

    Senktide's action is linked to the modulation of dopaminergic systems, evidenced by the reversal of its locomotor effects with dopamine D2 receptor antagonists. Additionally, synergistic interactions with tachykinin NK1 receptor antagonism highlight complex receptor cross-talk mechanisms. The peptide's behavioral effects, including foot tapping and locomotion, vary with dose, reflecting its role in studying tachykinin NK3 receptor signaling pathways.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Nordquist RE, Durkin S, Jacquet A, Spooren W. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. doi: 10.1016/j.ejphar.2008.10.011. Epub 2008 Oct 10. PMID: 18930726.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"