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  • SEB Domain (152-161) peptide

SEB Domain (152-161) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319790

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    SEB Domain (152-161) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-KKKVTAQELD-OH
  • Sequence
    H-Lys-Lys-Lys-Val-Thr-Ala-Gln-Glu-Leu-Asp-OH
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    95.08%
  • Molecular Formula
    C50H90N14O17
  • Molecular Weight
    1159.33
  • CAS No.
    210229-94-0
  • PubChem CID
    155977565
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The peptide KKKVTAQELD is a highly conserved sequence found in staphylococcal enterotoxins (SE), including SEB, SEA, SEE, and TSST-1. Structural analysis reveals that this region encompasses the end of beta sheet 7, beta sheet 8, and the beginning of helix 4, a conformation preserved across SE. Experimental studies demonstrate that synthetic peptides containing this sequence significantly inhibit the transcytosis of SEB across epithelial cell monolayers, reducing movement by up to 85% at a toxin-to-peptide ratio of 1:10. The inhibitory effect extends to other SE, such as SEA, SEE, and TSST-1, indicating a conserved functional role in toxin translocation. Antisera generated against this peptide recognize native SEB and also block transcytosis, further confirming its involvement in epithelial barrier crossing.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Shupp JW, Jett M, Pontzer CH. Identification of a transcytosis epitope on staphylococcal enterotoxins. Infect Immun. 2002 Apr;70(4):2178-86. doi: 10.1128/IAI.70.4.2178-2186.2002. PMID: 11895985; PMCID: PMC127880.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"