Recombinant SCN2A protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

This recombinant protein product features a fragment (residues 1357-1447) of the human Sodium channel protein type 2 subunit alpha (Nav1.2), encoded by the SCN2A gene. This 91-amino acid fragment has been computationally selected for its stability and solubility, making it an ideal tool for structural studies and biochemical assays targeting voltage-gated sodium channel function.

The full-length Sodium channel protein type 2 subunit alpha (Nav1.2) mediates voltage-dependent sodium ion permeability in excitable membranes. It functions by transitioning between open and closed conformations in response to membrane voltage changes, forming a sodium-selective channel that allows Na+ ions to pass according to their electrochemical gradient. This protein is implicated in hippocampal replay events within sharp wave ripples, which are critical for memory processes. It is localized to the cell membrane as a multi-pass membrane protein, underscoring its role in neuronal excitability and signal transduction.