Sarilesin peptide

Sarilesin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

XRVYIHPI, X is sarcosine

Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH

7

95.42%

C₄₆H₇₃N₁₃O₁₀

968.17

Synthetic

Powder

Sarilesin, also known as [Sar1,Ile8]-angiotensin II, is a specific antagonist at angiotensin receptors. Sarilesin has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels. Sarilesin activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Obermüller et al (1991) Distribution of angiotensin II receptor subtypes in rat brain nuclei. Neurosci. Lett. 132(1) 11 PMID: 1787912
• Matsoukas et al (1993) Synthesis and biological activities of angiotensin II, Sarilesin, and Sarmesin analogues containing Aze or Pip at position 7. J. Med. Chem. 1993 36(7) 904 PMID: 8464045

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.