Sarconesin II peptide

Sarconesin II peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-VALTGLTVAEYFR-OH

H-Val-Ala-Leu-Thr-Gly-Leu-Thr-Val-Ala-Glu-Tyr-Phe-Arg-OH

13

95.2%

C₆₇H₁₀₆N₁₆O₁₉

1439.65

Synthetic

Powder

Sarconesin II is a new antimicrobial peptides isolated from Sarconesiopsis magellanica excretions and secretions. Sarconesin II was documented as a conserved domain of the ATP synthase protein belonging to the Fli-1 superfamily. A BLAST search for Calliphoridae multiple sequence alignment revealed sarconesin II’s 100% matching identity with the mitochondrial ATP synthase subunit beta, appearing as a putative conserved domain of the Fli-1 superfamily: flagellar biosynthesis/type III secretory pathway ATPase (Accession: cl25576). Sarconesin II and the conserved domain also appeared in other organisms, such as Homo sapiens (Sequence ID: gi|179279|AAA51808.1), Drosophila melanogaster (gi|442614522|NP_001259081.1) and Mus musculus (gi|31980648|NP_058054.2). Sarconesin II is predicted to have a typical alpha-helix structure. Sarconesin II induced alterations in E. coli cell morphology. Sarconesin II had good activity against Gram-negative and Gram-positive bacteria, including E. coli K12 MG1655.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Du00edaz-Roa A, Espinoza-Culupu00fa A, Torres-Garcu00eda O, et al. Sarconesin II, a New Antimicrobial Peptide Isolated from Sarconesiopsis magellanica Excretions and Secretions. Molecules. 2019;24(11)

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.