Sarafotoxin S6c/SXS6c peptide

Sarafotoxin S6c/SXS6c peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-CTCNDMTDEECLNFCHQDVIW-OH

H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH

21

95.9%

C₁₀₃H₁₄₇N₂₇O₃₇S₅

2515.74

121695-87-2

254764411

Synthetic

Powder

Sarafotoxin S6c (SXS6c) is a potent vasoconstrictor peptide that belongs to the sarafotoxin family, which is derived from the venom of certain snake species, particularly the African mamba. SXS6c primarily acts as an agonist for the endothelin B (ETB) receptor, although it has some affinity for endothelin A (ETA) receptors as well. This interaction leads to vasoconstriction, which is the narrowing of blood vessels, resulting in increased blood pressure. SXS6c is often used in pharmacological studies to investigate the role of endothelin receptors in vascular physiology and pathophysiology, particularly in conditions such as pulmonary hypertension. It helps researchers understand how endothelin signaling contributes to vascular tone and blood pressure regulation.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• MacLean MR, McCulloch KM, Baird M. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. doi: 10.1097/00005344-199511000-00020. PMID: 8637198.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.