SAMβA, βIIPKC_624-632 peptide

SAMβA, βIIPKC_624-632 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RNAENFDRF-NH2

H-Arg-Asn-Ala-Glu-Asn-Phe-Asp-Arg-Phe-NH2

9

95.2%

C₅₀H₇₄N₁₈O₁₅

1167.23

Synthetic

Powder

SAMβA(βIIPKC_624-632) is a 9-amino-acid peptide(sequence: RNAENFDRF) which is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. SAMβA may be a potential treatment for heart failure. Treatment of cultured neonatal cardiac myocytes with SAMβA prevented mitochondrial fragmentation triggered by angiotensin II. SAMβA reduced the excessive association of βIIPKC with Mfn1 induced by angiotensin II in cardiac myocytes, as measured by co-immunoprecipitation. The treatment of cardiac neonatal myocytes with SAMβA had a better effect in protecting against H2O2-induced metabolic dysfunction when compared to the global βIIPKC inhibitor, βIIV5-3.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Ferreira, J. C. B., Campos, J. C., Qvit, N., Qi, X., Bozi, L. H. M., Bechara, L. R. G., u2026 Mochly-Rosen, D. (2019). A selective inhibitor of mitofusin 1-u03b2IIPKC association improves heart failure outcome in rats. Nature Communications, 10(1). https://doi.org/10.1038/s41467-018-08276-6

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.