Recombinant SACA3 protein (His tag)

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Recombinant Human SPACA3 (Sperm Acrosome Membrane-Associated Protein 3) Fragment (aa 85-215) is a highly purified protein designed for studying sperm-egg membrane interactions during fertilization. This fragment encompasses the complete C-type lysozyme domains, offering a targeted tool for investigating acrosomal protein function in reproductive biology.

Sperm Acrosome Membrane-Associated Protein 3 (SPACA3), also known as Cancer/Testis Antigen 54, is a sperm surface membrane protein implicated in sperm-egg plasma membrane adhesion and fusion during fertilization. The protein may function as a receptor for N-acetylglucosamine oligosaccharide residues present in the egg extracellular matrix. SPACA3 localizes to the acrosome membrane in cytoplasmic vesicles and exists as both membrane-anchored (isoform 1) and secreted (isoform 2) forms. While the processed form shows no detectable bacteriolytic activity, the full-length protein plays a crucial role in reproductive processes. The recombinant fragment (aa 85-215) contains the complete C-type lysozyme domains, enabling focused investigation of these functional regions without interference from other protein segments.