Recombinant SAA1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Serum amyloid A-1 protein (SAA) fragment (residues 19-122) is a high-quality, stable protein preparation ideal for structural biology and biochemical research. This 104-amino acid fragment represents a computationally optimized, soluble domain of the major acute phase protein SAA, providing researchers with a reliable tool for studying inflammation and amyloid formation mechanisms.

Serum amyloid A-1 protein (SAA) functions as a major acute phase protein, playing a critical role in the inflammatory response. As an acute phase reactant, SAA levels increase dramatically during inflammation, infection, and tissue injury, making it a valuable biomarker for inflammatory conditions. The protein is naturally secreted into the extracellular space, where it participates in immune modulation and can undergo proteolytic processing to form amyloid protein A, the primary component of amyloid fibrils in secondary amyloidosis. The full-length protein undergoes extensive cleavage, generating multiple isoforms including amyloid protein A and various serum amyloid protein A fragments, highlighting its complex biological processing and functional diversity in inflammatory pathways.

19-122