S7 peptide

S7 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-LSLITRL-OH

H-Leu-Ser-Leu-Ile-Thr-Arg-Leu-OH

7

95.36%

C₃₇H₇₀N₁₀O₁₀

815.01

Synthetic

Powder

S7 is a peptide identified from a phage display library, which selectively binds to the interleukin-6 receptor (IL-6R) alpha chain (gp80) and inhibits IL-6 mediated events. S7 can inhibit IL-6 induced VEGF-A expression and angiogenesis in different cancer cell lines, and can prevent IL-6 mediated survival signalling and sensitise cervical cancer cells to chemotherapy. S7 is bioavailable in vivo, and can induce apoptopic cell death and suppress IL-6 induced tumour growth in mouse models.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Su et al (2005) A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res. 65(11) 4827 PMID: 15930303
• Figueiredo et al (2020) Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo. Mol. Ther. Methods Clin. Dev. 17 739 PMID: 32346551
• Figueiredo et al (2021) Reengineering Tumor Microenvironment with Sequential Interleukin Delivery. Bioengineering 8(7) 90 PMID: 34209203

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.