S6 Phosphate Acceptor Peptide, S6-1

S6 Phosphate Acceptor Peptide, S6-1

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

RRLSSLRA

H-Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala-OH

8

97.1%

C₃₉H₇₅N₁₇O₁₁

958.13

93674-74-9

Synthetic

Powder

This peptide is based on the sequence of a region of rat hepatic ribosomal protein S6 which contains the major phosphorylation site for cAMP-dependent protein kinase and one of the insulin-stimulated phosphorylation sites. It has been shown to be a substrate for cAMP-dependent protein kinase, for protein kinase C, and for the ribosomal protein S6 kinases (p70S6K and p85S6K isoforms, as well as insulin-stimulated p90rsk).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• B.Gabrielli et al., FEBS Lett., 175, 219 (1984)
• S.Ferrari et al., FEBS Lett., 184, 72 (1985)
• S.L.Pelech et al., Proc. Natl. Acad. Sci. USA, 83, 5968 (1986)
• H.Flotow and G.Thomas, J. Biol. Chem., 267, 3074 (1992)
• D.E.Joseph et al., J. Biol. Chem., 271, 13088 (1996)

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.