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Product Name
Recombinant S28A2 protein (His tag)
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Description
This product is a recombinant protein fragment of Sodium/nucleoside cotransporter 2 (SLC28A2), spanning residues 588-658. This 71-amino acid fragment represents a stable, soluble unit of the human concentrative nucleoside transporter, ideal for structural studies and biochemical characterization of this crucial purine nucleoside transporter.
The full-length Sodium/nucleoside cotransporter 2 (CNT2) is a sodium-dependent, purine-selective transporter that exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype. It plays a critical role in the specific uptake and salvage of purine nucleosides and uridine in kidney and other tissues. Recent evidence suggests it may contribute to regulating organic compound transport across the blood-testis barrier. The protein is localized to cellular membranes as a multi-pass membrane protein, with specific apicolateral membrane localization observed in Sertoli cells and vascular endothelial cells in testis, indicating its importance in specialized transport functions in these tissues.
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Protein name
Sodium/nucleoside cotransporter 2
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Uniprot ID
O43868
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Gene Name
SLC28A2; CNT2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 588-658 aa (O43868) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 9.46 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 9 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"