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Product Name
Recombinant RXRB protein (His tag)
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Description
Introducing the recombinant human Retinoic acid receptor RXR-beta (RXRβ) fragment (residues 203-533), a high-purity protein designed to encompass the NR LBD domain. This fragment serves as an essential tool for investigating retinoic acid signaling, ligand binding, and gene regulation mechanisms in nuclear receptor research.
Retinoic acid receptor RXR-beta (RXRβ), encoded by the RXRB gene, functions as a receptor for retinoic acid, binding as heterodimers to retinoic acid response elements (RARE) in response to ligands such as all-trans or 9-cis retinoic acid. It plays a critical role in regulating gene expression across diverse biological processes. The protein is localized primarily in the nucleus, with additional presence observed in the cytoplasm, highlighting its dynamic involvement in cellular signaling pathways.
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Protein name
Retinoic acid receptor RXR-beta
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Uniprot ID
P28702
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Gene Name
RXRB; NR2B2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 203-533 aa (P28702) were fused with C-terminal 6His tag.
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Sequence
MSKIKRLCAI CGDRSSGKHY GVYSCEGCKG FFKRTIRKDL TYSCRDNKDC TVDKRQRNRC QYCRYQKCLA TGMKREAVQE ERQRGKDKDG DGEGAGGAPE EMPVDRILEA ELAVEQKSDQ GVEGPGGTGG SGSSPNDPVT NICQAADKQL FTLVEWAKRI PHFSSLPLDD QVILLRAGWN ELLIASFSHR SIDVRDGILL ATGLHVHRNS AHSAGVGAIF DRVLTELVSK MRDMRMDKTE LGCLRAIILF NPDAKGLSNP SEVEVLREKV YASLETYCKQ KYPEQQGRFA KLLLRLPALR SIGLKCLEHL FFFKLIGDTP IDTFLMEMLE APHQLALEHH HHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 38.63 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 40 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant RXRB protein (His tag) SDS-PAGE
M: Marker; Lane 1: RXRB; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"