Rusfertide peptide

Rusfertide peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

{Asp(N-(3-methyl-1-oxobutyl))}-THFPCI-{Lys(γGlu-C16 acid)}-FEPRSKGCK-NH2 (disulfide bridge: Cys6-Cys16)

{Asp(N-(3-methyl-1-oxobutyl))}-Thr-His-Phe-Pro-Cys-Ile-{Lys(γGlu-C16 acid)}-Phe-Glu-Pro-Arg-Ser-Lys-Gly-Cys-Lys-NH2 (disulfide bridge: Cys6-Cys16)

17

95.46%

C₁₁₄H₁₈₁N₂₇O₂₈S₂

2442

1628323-80-7

155884410

Synthetic

Powder

Rusfertide(PTG-300) is a peptide mimetic of natural hepcidin, which targets the major iron transporter, ferroportin, and causes its internalization and subsequent degradation. This leads to reductions in serum iron and transferrin saturation (TSAT) due to reduced ferroportin expression on cells that store or recycle iron. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Roopa Taranath, Gregory Bourne, Li Zhao, Brian Frederick, Chelsea King, David Liu, Regulation of Iron Homeostasis By PTG-300 Improves Disease Parameters in Mouse Models for Beta-Thalassemia and Hereditary Hemochromatosis, Blood, Volume 134, Supplement 1, 2019, Page 3540, ISSN 0006-4971, https://doi.org/10.1182/blood-2019-129309.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.