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Recombinant RRN3 protein (His tag)

Recombinant RRN3 protein (His tag)

Cat.#: 543767

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Special Price 383.1 USD

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Product Information

  • Product Name
    Recombinant RRN3 protein (His tag)
  • Documents
  • Description

    This product is a recombinant fragment of the human RNA polymerase I-specific transcription initiation factor RRN3 (also known as TIF-IA), spanning residues 304-583. It is designed as a stable, soluble unit ideal for structural studies and biochemical assays investigating transcription initiation mechanisms.

    The full-length RRN3 protein is essential for efficient transcription initiation by RNA polymerase I (Pol I), playing a critical role in forming the competent pre-initiation complex (PIC) required for ribosomal RNA synthesis. It localizes to the nucleus, specifically within the nucleolus, where it facilitates Pol I-driven gene expression. This fragment was selected computationally to ensure stability and solubility, enabling detailed analysis of its functional properties without the complexities of the full-length protein.

  • Protein name
    RNA polymerase I-specific transcription initiation factor RRN3
  • Uniprot ID
    Q9NYV6
  • Gene Name
    RRN3; TIFIA
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 304-583 aa (Q9NYV6) were fused with 6His tag.
  • Sequence 
    304-583
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 33.85 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 34 kDa band.
  • Purity
    >87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"