Recombinant RRAS protein (His tag)

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Recombinant Human R-Ras (Ras-related protein R-Ras, EC 3.6.5.2) fragment (residues 1-215) is a high-quality, soluble protein designed for structural and biochemical studies. This fragment captures the essential GTPase domain, enabling researchers to investigate its role in MAPK signaling and cytoskeletal organization with enhanced stability and experimental utility.

R-Ras is a GTP-binding protein with intrinsic GTPase activity, primarily involved in regulating the MAPK signaling pathway, which governs diverse cellular processes. It plays a critical role in actin cytoskeleton organization and, in conjunction with OSPBL3, modulates integrin beta-1 (ITGB1) activity, influencing cell adhesion and motility. The full-length protein is localized to the inner surface of the plasma membrane, anchored via lipid modification at its C-terminal cysteine, consistent with its function in membrane-associated signaling. This recombinant fragment (1-215) encompasses the complete functional domain, providing a reliable tool for exploring R-Ras mechanisms in cellular regulation.