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Recombinant ROBO4 protein (His tag)

Recombinant ROBO4 protein (His tag)

Cat.#: 538628

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Special Price 294.7 USD

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Product Information

  • Product Name
    Recombinant ROBO4 protein (His tag)
  • Documents
  • Description

    Recombinant Human ROBO4 (Roundabout homolog 4, Magic roundabout) fragment (aa 28-494) is a high-purity protein designed for studying angiogenesis and vascular integrity. This fragment includes key functional domains—Ig-like C2-type 1 and 2, and Fibronectin type-III 1 and 2—making it an essential tool for targeted research on endothelial signaling and barrier function.

    Roundabout homolog 4 (ROBO4) is a receptor for Slit proteins, such as SLIT2, and plays a critical role in angiogenesis, vascular patterning, and the inhibition of endothelial cell migration. It contributes to the maintenance of endothelial barrier organization and function, as supported by studies (e.g., PubMed:30455415). The full-length protein's involvement in these processes underscores its importance in cardiovascular and vascular biology research, though subcellular localization details are not specified in the provided data.

  • Protein name
    Roundabout homolog 4
  • Uniprot ID
    Q8WZ75
  • Gene Name
    ROBO4
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 28-494 aa (Q8WZ75) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 52.14 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 52 kDa band.
  • Purity
    >89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"