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  • RI-EXT peptide

RI-EXT peptide

Not For Human Use, Lab Use Only.

Cat.#: 318874

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* Buy 1 get 1 free (?) What is TFA?

Special Price 328.90 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    RI-EXT peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    ffGGreGcvlylaevlhsG (lower case letters on behalf of D-amino acid)
  • Sequence
    H-D-Phe-D-Phe-Gly-Gly-D-Arg-D-Glu-Gly-D-Cys-D-Val-D-Leu-D-Tyr-D-Leu-D-Ala-D-Glu-D-Val-D-Leu-D-His-D-Ser-Gly-OH
  • Length (aa)
    19
  • Peptide Purity (HPLC)
    95.2%
  • Molecular Formula
    C94H140N24O26S
  • Molecular Weight
    2054.32
  • Source
    Synthetic
  • Form
    Powder
  • Description
    There is no cure or prevention treatment for Type 1 Diabetes (T1D). Insulin peptide InsB:9-23 (SHLVEALYLVCGERG) and HLA-DQ8 molecule are key elements in T1D development. A retro-inverso-d-amino acid based peptide RI-EXT (ffGGreGcvlylaevlhsG) could block the binding between InsB:9-23 and HLA-DQ8. RI-EXT blocks the presentation of InsB:9-23 to autoreactive T-cells. RI-EXT could lead to innovative therapies for the treatment of T1D.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Lombardi, A., Concepcion, E., Hou, H., Arib, H., Mezei, M., Osman, R., & Tomer, Y. (2020). Retro-inverso D-peptides as a novel targeted immunotherapy for Type 1 diabetes. Journal of Autoimmunity, 115, 102543.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-FFGGREGCVLYLAEVLHSG-OH
  • Chemical Formula:C94H140N24O26S
  • Sequence length:19
  • Extinction coefficient:1280 M-1cm-1
  • GRAVY:0.59
  • Mw average:2054.32
  • Theoretical pI:5.3
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"