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Product Name
Recombinant RHEB1 protein (His tag)
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Description
Recombinant GTP-binding protein Rheb homolog 1 (EC 3.6.5.-) fragment (residues 1-204) from Caenorhabditis elegans, representing a stable and soluble unit optimized for structural and biochemical studies. This fragment retains intrinsic GTPase activity and GTP-binding capability, making it ideal for investigating mTOR signaling pathways and cellular growth regulation.
The full-length GTP-binding protein Rheb homolog 1 binds GTP and exhibits intrinsic GTPase activity, functioning as a key regulator in cellular signaling pathways, particularly in mTOR-mediated processes that control cell growth and proliferation. It localizes to the cell membrane via lipid anchoring on the cytoplasmic side, where it interacts with downstream effectors. The recombinant fragment (residues 1-204) encompasses the complete functional domain, enabling researchers to study its mechanistic role in GTP hydrolysis and signal transduction without solubility issues.
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Protein name
GTP-binding protein Rheb homolog 1
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Uniprot ID
P34443
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Gene Name
rheb-1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-204 aa (P34443) were fused with 6His tag.
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 25.06 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 26 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"