RGDFF peptide

RGDFF peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RGDFF-OH

H-Arg-Gly-Asp-Phe-Phe-OH

5

95.43%

C₃₀H₄₀N₈O₈

640.68

Synthetic

Powder

RGDFF is an amphiphilic pentapeptide which could be coassemble with the thiol-activated H2S donors (CL2/3) into nanocarriers for targeted therapy of non-small-cell lung cancer. The coassembly approach simply solved the solubility issue of CL2/3 by the introduction of electron-donating groups (phenyl rings) to slow down the H2S release while dramatically improving their biocompatible interface, circulation time, slow release of H2S, and tumor targeting.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Chen H, Guan X, Liu Q, Yang L, Guo J, Gao F, Qi Y, Wu X, Zhang F, Tian X. Co-assembled Nanocarriers of De Novo Thiol-Activated Hydrogen Sulfide Donors with an RGDFF Pentapeptide for Targeted Therapy of Non-Small-Cell Lung Cancer. ACS Appl Mater Interfaces. 2022 Dec 7;14(48):53475-53490. doi: 10.1021/acsami.2c14570. Epub 2022 Nov 22. PMID: 36413755.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.