RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2) peptide
Not For Human Use, Lab Use Only.
Cat.#: 318729
Special Price 214.50 USD
Availability:
1-2 weeks
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Product Name
RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2) peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
SPLERNAIKGYRYLSTR-NH2
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Sequence
H-Ser-Pro-Leu-Glu-Arg-Asn-Ala-Ile-Lys-Gly-Tyr-Arg-Tyr-Leu-Ser-Thr-Arg-NH2
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Length (aa)
17
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Peptide Purity (HPLC)
97.2%
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Molecular Formula
C89H147N29O25
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Molecular Weight
2023.29
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Source
Synthetic
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Form
Powder
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Description
RGBA-1-2b peptide was first reported in paper:Yin J-A, Gao G, Liu X-J, et al. Genetic variation in glia–neuron signalling modulates ageing rate. Nature. 2017;551(7679):198-203. doi:10.1038/nature24463. RGBA-1(regulartory gene for behavioural ageing 1) activates NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. Four neuropeptides derived from RGBA-1 were identified by tandem mass spectrometry from N2 worms. RGBA-1-2b peptide(Sequence: SPLERNAIKGYRYLSTR-NH2) could activate NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. This signalling involves the SIR-2.1-dependent activation of the mitochondrial unfolded protein response, a pathway that modulates ageing. Thus, natural variation in neuropeptide-mediated glia–neuron signalling modulates the rate of ageing in C. elegans.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Yin J-A, Gao G, Liu X-J, et al. Genetic variation in glia-neuron signalling modulates ageing rate. Nature. 2017;551(7679):198-203. doi:10.1038/nature24463.
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Peptide Property
- Analysed Sequence:A
- Chemical Formula:A
- Sequence length:A
- Extinction coefficient:A M-1cm-1
- GRAVY:A
- Mw average:A
- Theoretical pI:A
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
X: Hydrophobic uncharged residues, like F I L M V W A and P
X: Basic residues, like R K H
X: Acidic residues, like D E
X: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"