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catalog peptide: RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2)

RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2)

Cat.#: 318729

Special Price 195.0 USD

Availability: 1-2 weeks

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Description
RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2)
Quantity/Unit 1 Vial
Sequence SPLERNAIKGYRYLSTR-NH2
Three letter code H-Ser-Pro-Leu-Glu-Arg-Asn-Ala-Ile-Lys-Gly-Tyr-Arg-Tyr-Leu-Ser-Thr-Arg-NH2
Length 17
Peptide Purity (%) 97.2
Molecular Formula C89H147N29O25
Molecular Weight 2023.31
Source Synthetic
Additional Information RGBA-1-2b peptide was first reported in paper:Yin J-A, Gao G, Liu X-J, et al. Genetic variation in glia–neuron signalling modulates ageing rate. Nature. 2017;551(7679):198-203. doi:10.1038/nature24463. RGBA-1(regulartory gene for behavioural ageing 1) activates NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. Four neuropeptides derived from RGBA-1 were identified by tandem mass spectrometry from N2 worms. RGBA-1-2b peptide(Sequence: SPLERNAIKGYRYLSTR-NH2) could activate NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. This signalling involves the SIR-2.1-dependent activation of the mitochondrial unfolded protein response, a pathway that modulates ageing. Thus, natural variation in neuropeptide-mediated glia–neuron signalling modulates the rate of ageing in C. elegans.
Storage Guidelines Ideally RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2) should be stored in a freezer at or below -9C. RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2) should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
Terms Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.
References

Yin J-A, Gao G, Liu X-J, et al. Genetic variation in glia–neuron signalling modulates ageing rate. Nature. 2017;551(7679):198-203. doi:10.1038/nature24463.

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