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  • RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2)

RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2)

Cat.#: 318729

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Product Information

  • Product Name
    RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2)
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    SPLERNAIKGYRYLSTR-NH2
  • Three letter code
    H-Ser-Pro-Leu-Glu-Arg-Asn-Ala-Ile-Lys-Gly-Tyr-Arg-Tyr-Leu-Ser-Thr-Arg-NH2
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    97.2
  • Molecular Formula
    C89H147N29O25
  • Molecular Weight
    2023.29
  • Source
    Synthetic
  • Additional Information
    RGBA-1-2b peptide was first reported in paper:Yin J-A, Gao G, Liu X-J, et al. Genetic variation in glia–neuron signalling modulates ageing rate. Nature. 2017;551(7679):198-203. doi:10.1038/nature24463. RGBA-1(regulartory gene for behavioural ageing 1) activates NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. Four neuropeptides derived from RGBA-1 were identified by tandem mass spectrometry from N2 worms. RGBA-1-2b peptide(Sequence: SPLERNAIKGYRYLSTR-NH2) could activate NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. This signalling involves the SIR-2.1-dependent activation of the mitochondrial unfolded protein response, a pathway that modulates ageing. Thus, natural variation in neuropeptide-mediated glia–neuron signalling modulates the rate of ageing in C. elegans.
  • Storage Guidelines
    Ideally RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2) should be stored in a freezer at or below -9C. RGBA-1-2b (SPLERNAIKGYRYLSTR-NH2) should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Yin J-A, Gao G, Liu X-J, et al. Genetic variation in glia–neuron signalling modulates ageing rate. Nature. 2017;551(7679):198-203. doi:10.1038/nature24463.

Peptide Property

  • Analysed Sequence:H-SPLERNAIKGYRYLSTR-Amidation
  • Chemical Formula:C89H147N29O25
  • Sequence length:17
  • Extinction coefficient:2560 M-1cm-1
  • GRAVY:-1.02
  • Mw average:2023.29
  • Theoretical pI:10.54
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

Red: Hydrophobic uncharged residues, like F I L M V W A and P

Blue: Basic residues, like R K H and N-terminal -NH2

Green: Acidic residues, like D E and C-terminal -COOH

Black: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"