-
Product Name
Recombinant RFX5 protein (His tag)
- Documents
-
Description
Recombinant Human DNA-binding protein RFX5 (Regulatory factor X 5), fragment 2-248, is a high-purity protein designed for structural and biochemical studies. This 247-amino acid fragment was computationally optimized for stability and solubility, enabling reliable investigation of RFX5's role in MHC-II transcriptional activation.
RFX5 is a key transcription factor in humans that activates class II major histocompatibility complex (MHC) promoters by recognizing X-box DNA elements. It functions in the nucleus, where it mediates cooperative binding with NF-Y and specifically interacts with the X1 box of MHC-II promoters to regulate immune response gene expression. This nuclear protein is essential for MHC-II-mediated antigen presentation and immune system coordination.
-
Protein name
DNA-binding protein RFX5
-
Uniprot ID
P48382
-
Gene Name
RFX5
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 2-248 aa (P48382) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 29.05 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 29 kDa band.
-
Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"