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Product Name
Recombinant REXO1 protein (His tag)
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Description
Recombinant Human REXO1 (RNA exonuclease 1 homolog) Fragment (residues 803-1221) is a high-purity protein designed for studying exonuclease domain functions. This 419-amino acid fragment fully encompasses the exonuclease domain (residues 1060-1209), providing an ideal tool for targeted functional investigations.
The full-length REXO1 protein, also known as Elongin-A-binding protein 1 or EloA-BP1, is localized to the nucleus according to experimental evidence. Based on published research, REXO1 appears to have no detectable effect on transcription elongation in vitro. This suggests that while it interacts with transcription elongation machinery components, its primary function may lie outside direct transcriptional regulation. The nuclear localization indicates potential roles in RNA processing or degradation pathways, making this exonuclease-containing fragment particularly valuable for investigating these specific molecular mechanisms.
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Protein name
RNA exonuclease 1 homolog
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Uniprot ID
Q8N1G1
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Gene Name
REXO1; ELOABP1; KIAA1138; TCEB3BP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 803-1221 aa (Q8N1G1) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 48.53 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 50 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"