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Product Name
Recombinant RENI protein (His tag)
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Description
Recombinant Human Renin (EC 3.4.23.15) Fragment (67-406) is a highly specific endopeptidase designed for studying angiotensin I generation and blood pressure regulation. This 340-amino acid fragment fully encompasses the functional Peptidase A1 domain, making it an ideal tool for targeted functional and mechanistic investigations.
Renin, also known as angiotensinogenase, is a key enzyme in the renin-angiotensin system, where its sole known function is to cleave angiotensinogen to produce angiotensin I. This reaction initiates a critical cascade leading to increased blood pressure and enhanced renal sodium retention, positioning renin as a central regulator of cardiovascular and renal physiology. The enzyme is naturally secreted and can associate with membranes via binding to ATP6AP2, reflecting its dynamic role in both soluble and membrane-bound contexts. The provided fragment retains these essential functional characteristics while enabling focused domain-specific research.
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Protein name
Renin
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Uniprot ID
P00797
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Gene Name
REN
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 67-406 aa (P00797) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 38.89 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 39 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"