Recombinant RCAN1 protein (His tag)

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Recombinant Calcipressin-1 (RCAN1) Fragment (63-252) is a high-purity, stable protein derived from human Calcipressin-1, designed for structural and biochemical studies. This 190-amino acid fragment retains key functional properties, offering researchers a reliable tool to investigate calcineurin regulation and its implications in cellular signaling and neurological development.

Calcipressin-1, encoded by the RCAN1 gene, is a critical regulator of calcineurin, a calcium-dependent phosphatase involved in numerous cellular processes. It inhibits calcineurin-dependent transcriptional responses by binding directly to the catalytic domain of calcineurin A, modulating signaling pathways essential for cellular adaptation and development. Research suggests a potential role in central nervous system development, highlighting its importance in neurobiology and disease contexts such as Down syndrome, where its dysregulation may contribute to pathological outcomes. The provided fragment (63-252) was selected for its stability and solubility, enabling detailed mechanistic studies without the full-length protein's complexities.