Recombinant RBM3 protein (His tag)

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Recombinant Human RNA-binding protein 3 (RBM3) Fragment (residues 1-82) is a high-quality, stable protein product designed for structural and biochemical studies. This fragment, derived from the cold-inducible mRNA-binding protein RBM3, offers a soluble and functional unit ideal for investigating protein-RNA interactions and its role in enhancing global protein synthesis under physiological and mild hypothermic conditions.

RNA-binding protein 3 (RBM3) is a cold-inducible mRNA-binding protein that plays a critical role in enhancing global protein synthesis at both physiological and mild hypothermic temperatures. It functions by reducing the relative abundance of microRNAs when overexpressed and promotes phosphorylation of translation initiation factors and active polysome formation, facilitating efficient protein production. RBM3 localizes to the nucleus, cytoplasm, and cell projections such as dendrites, where it is found in mRNA granules, underscoring its importance in mRNA transport and localized translation within neuronal processes. This recombinant fragment represents a stable, soluble region of RBM3, enabling detailed exploration of its molecular mechanisms in cellular stress responses and translational regulation.