Recombinant RAGE protein (His tag)

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Recombinant Human AGER (Advanced Glycosylation End Product-Specific Receptor) Fragment (aa 23-322) is a high-purity protein encompassing the complete Ig-like V-type and C2-type domains, designed for studying ligand interactions, inflammatory signaling, and receptor function in diabetes, neurodegeneration, and cancer research.

The full-length AGER protein, encoded by the AGER gene in Homo sapiens, is a cell surface pattern recognition receptor that binds diverse endogenous stress signals, including advanced glycation end products, S100 proteins, HMGB1, amyloid-beta oligomers, nucleic acids, and histones. It transduces ligand binding into pro-inflammatory responses via TIRAP and MYD88 adapters, activating NF-kB to induce cytokines like IL6, IL8, and TNFalpha. AGER contributes to pathologies such as diabetes, vascular complications, neurodegenerative disorders, and cancers by promoting inflammation, reactive oxygen species production, and cellular activation. It also facilitates amyloid-beta translocation in neurons, endothelial albumin transcytosis, phagocytosis of pathogens and apoptotic cells, and DNA damage repair by stabilizing replication forks and enhancing MRE11 endonuclease activity. Subcellularly, it localizes to the cell membrane, phagocytic cups, early endosomes, and the nucleus, with nuclear translocation increased under DNA damage or stress conditions. Isoforms include membrane-bound and secreted forms, highlighting its versatile roles in immunity and disease.