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Product Name
Recombinant RAB5C protein (His tag)
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Description
Recombinant Human Ras-related protein Rab-5C (RAB5C) fragment (residues 1-185) is a high-purity, stable protein designed for structural and biochemical studies. This soluble fragment retains key functional characteristics, making it an ideal tool for investigating intracellular membrane trafficking mechanisms in research applications.
Ras-related protein Rab-5C is a small GTPase that serves as a critical regulator of intracellular membrane trafficking. It cycles between GDP-bound (inactive) and GTP-bound (active) states to control processes including transport vesicle formation, movement, tethering, and fusion. The protein localizes to the cell membrane (cytoplasmic side), early endosome membrane (via lipid-anchor), and melanosomes, playing essential roles in endocytic pathways and organelle dynamics. This recombinant fragment represents a stable, soluble unit optimized for experimental analysis of Rab-5C function.
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Protein name
Ras-related protein Rab-5C
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Uniprot ID
P51148
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Gene Name
RAB5C; RABL
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-185 aa (P51148) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 21.88 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 22 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"