Recombinant RAB23 protein (His tag)

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Introducing the recombinant human Ras-related protein Rab-23 (EC 3.6.5.2) fragment (amino acids 1-182), a highly stable and soluble unit ideal for investigating intracellular membrane trafficking, autophagy, and Hedgehog signaling pathways. This fragment is expertly designed for structural and biochemical studies, offering researchers a reliable tool to explore Rab-23's regulatory roles in cellular processes.

Ras-related protein Rab-23 is a small GTPase that functions as a key regulator of intracellular membrane trafficking, cycling between inactive GDP-bound and active GTP-bound forms to control vesicle formation, movement, tethering, and fusion. It plays critical roles in inhibiting GLI1 transcription factor activity in conjunction with SUFU, regulating GLI3 proteolytic processing, and modulating GLI2 and GLI3 activities, particularly in chondrocyte differentiation. Additionally, Rab-23 is involved in autophagic vacuole assembly and pathogen defense by promoting the capture of pathogens like Staphylococcus aureus into autophagosomes for lysosomal degradation. Subcellularly, it localizes to the cell membrane (lipid-anchored on the cytoplasmic side), cytoplasm, autophagosomes, endosome membranes, and phagosomes, where it is recruited during immune responses. This protein's multifaceted functions make it significant in studies of cellular transport, development, and host-pathogen interactions.