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  • R-DIM-P-LF11 peptide

R-DIM-P-LF11 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319252

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Product Information

  • Product Name
    R-DIM-P-LF11 peptide
  • Documents
  • Sequence Shortening
    H-FQWQRNIRKVRPRVKRINRQWQF-NH2
  • Sequence
    H-Phe-Gln-Trp-Gln-Arg-Asn-Ile-Arg-Lys-Val-Arg-Pro-Arg-Val-Lys-Arg-Ile-Asn-Arg-Gln-Trp-Gln-Phe-NH2
  • Length (aa)
    23
  • Peptide Purity (HPLC)
    95.59%
  • Molecular Formula
    C143H228N52O29
  • Molecular Weight
    3139.66
  • Source
    Synthetic
  • Form
    Powder
  • Description
    R-DIM-P-LF11 is a retro di-peptide with antitumor activity. R-DIM-P-LF11 had a low anticancer activity for A375 with a high LC50 value of 125 μM. Peptide R-DIM-P-LF11 did not cause release of LDH at any concentration with only 10% LDH released at the highest peptide concentration of 100 μM .
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Grissenberger S, Riedl S, Rinner B, Leber R, Zweytick D. Design of human lactoferricin derived antitumor peptides-activity and specificity against malignant melanoma in 2D and 3D model studies. Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183264. doi: 10.1016/j.bbamem.2020.183264. Epub 2020 Mar 7. PMID: 32151609.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"