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  • Pyrrhocoricin peptide

Pyrrhocoricin peptide

Not For Human Use, Lab Use Only.

Cat.#: 315639

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Pyrrhocoricin peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    VDKGSYLPRPTPPRPIYNRN-NH2
  • Sequence
    H-Val-Asp-Lys-Gly-Ser-Tyr-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-Asn-Arg-Asn-NH2
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95.79%
  • Molecular Formula
    C105H167N33O28
  • Molecular Weight
    2339.64
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Pyrrhocoricin is an insect-derived antimicrobial peptide. Its primary sequence is VDKGSYLPRPTPPRPIYNRN. This peptide interacts with the bacterial molecular chaperone DnaK, a member of the Hsp70 family. Studies indicate that pyrrhocoricin binds to the conventional substrate-binding site of DnaK. This binding event stimulates the ATPase activity of DnaK. The interaction is specific, as the all-D-amino acid isomer of the peptide does not exhibit binding. The peptide's mechanism involves competitive occupation of the chaperone's substrate-binding pocket.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Chesnokova LS, Slepenkov SV, Witt SN. The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK. FEBS Lett. 2004 May 7;565(1-3):65-9. doi: 10.1016/j.febslet.2004.03.075. PMID: 15135054.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"