Recombinant PTPR2 protein (His tag)

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Recombinant Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) fragment (residues 723-1015) is a high-purity protein designed for studying the tyrosine-protein phosphatase domain. This fragment supports research on vesicle-mediated secretory processes, insulin regulation, and actin dynamics, providing a focused tool for domain-specific functional assays.

Receptor-type tyrosine-protein phosphatase N2 (PTPRN2), encoded by the PTPRN2 gene in humans, plays a critical role in vesicle-mediated secretory processes. It is essential for the accumulation of secretory vesicles in pancreatic islets, hippocampus, and pituitary, and regulates insulin secretion in response to glucose. The protein also influences neurotransmitter levels (e.g., norepinephrine, dopamine, serotonin) and, in females, pituitary hormone secretion like luteinizing hormone and follicle-stimulating hormone. Additionally, it maintains renin expression and release, and exhibits phosphatidylinositol phosphatase activity, hydrolyzing substrates such as phosphatidylinositol 4,5-biphosphate (PI(4,5)P2) to indirectly regulate actin dynamics and cell migration. Located on dense-core secretory vesicle membranes, it transiently appears at the cell membrane during vesicle fusion and is recycled via clathrin-dependent endocytosis. The provided fragment encompasses the tyrosine-protein phosphatase domain, enabling targeted investigation of its catalytic and regulatory functions.

723-1015