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Product Name
Recombinant PSD1 protein (His tag)
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Description
Recombinant Human PSD Protein Fragment (aa 755-979) - A high-purity protein fragment containing the complete Pleckstrin Homology (PH) domain of PSD, designed for studying ARF6 guanine nucleotide exchange factor function and cytoskeletal remodeling mechanisms.
The full-length PH and SEC7 domain-containing protein 1 (PSD) functions as a guanine nucleotide exchange factor specifically for ARF6, playing a crucial role in cytoskeletal remodeling processes. This protein localizes to the cell membrane, ruffle membranes, and cleavage furrow, with dynamic redistribution during cell division - initially uniform on the plasma membrane during metaphase, then concentrating at the equatorial region during cytokinesis before returning to uniform plasma membrane distribution. These localization patterns underscore its importance in cell division and membrane dynamics.
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Protein name
PH and SEC7 domain-containing protein 1
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Uniprot ID
A5PKW4
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Gene Name
PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 755-979 aa (A5PKW4) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 27.10 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 27 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"