Recombinant PSB5 protein (His tag)

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Recombinant Human Proteasome subunit beta type-5 (PSMB5) fragment (residues 60-263) is a high-quality protein product designed for structural and biochemical studies. This fragment, selected for its stability and solubility, represents a key functional domain of the proteasome's chymotrypsin-like catalytic subunit, enabling detailed investigation into proteasomal mechanisms and ubiquitin-dependent protein degradation pathways.

Proteasome subunit beta type-5 (PSMB5) is an essential component of the 20S core proteasome complex, which mediates the proteolytic degradation of most intracellular proteins. As part of the 26S proteasome, it facilitates ATP-dependent degradation of ubiquitinated proteins, playing a critical role in maintaining protein homeostasis by eliminating misfolded, damaged, or obsolete proteins. PSMB5 exhibits chymotrypsin-like activity within the proteasome complex and also contributes to ubiquitin-independent degradation pathways when associated with regulators like PA200 or PA28, impacting processes such as spermatogenesis and MHC class I antigen presentation. The protein localizes to both the cytoplasm and nucleus, with nuclear translocation mediated by interaction with AKIRIN2 and the import receptor IPO9, underscoring its dynamic regulatory roles in cellular proteostasis.