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  • Ps-CATH4 peptide

Ps-CATH4 peptide

Not For Human Use, Lab Use Only.

Cat.#: 318769

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Ps-CATH4 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-TRGRWGRFKRRAGRFIRRNRWQIISTGLKLIG-OH
  • Sequence
    H-Thr-Arg-Gly-Arg-Trp-Gly-Arg-Phe-Lys-Arg-Arg-Ala-Gly-Arg-Phe-Ile-Arg-Arg-Asn-Arg-Trp-Gln-Ile-Ile-Ser-Thr-Gly-Leu-Lys-Leu-Ile-Gly-OH
  • Length (aa)
    32
  • Peptide Purity (HPLC)
    95.2%
  • Molecular Formula
    C175H291N65O38
  • Molecular Weight
    3913.58
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Cathelicidins are a class of gene-encoded immune effectors in vertebrate innate immune system. Ps-CATH4 is a novel cathelicidin which was found in Chinese soft-shell turtle (Pelodiscus sinensis). Ps-CATH4 was expressed in lung, spleen, liver, kidney, muscle, stomach and intestine. Ps-CATH4 showed the most potent and broad-spectrum antimicrobial activities against the tested pathogens, with the MICs mainly ranging from 2.34 μg/ml to 18.75 μg/ml. Ps-CATH6 showed relatively low antimicrobial activity. Ps-CATH4 and 6 showed relatively low cytotoxicity towards RAW264.7 cells, inducing 15.95% and 10.98% cell death, respectively. Ps-CATH4 showed more potent membrane permeabilization effect than Ps-CATH6, which is consistent with their different antimicrobial activities.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Shi N, Cai S, Gao J, et al. Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis. Dev Comp Immunol. 2019
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-TRGRWGRFKRRAGRFIRRNRWQIISTGLKLIG-OH
  • Chemical Formula:C175H291N65O38
  • Sequence length:32
  • Extinction coefficient:11380 M-1cm-1
  • GRAVY:-0.88
  • Mw average:3913.58
  • Theoretical pI:13.3
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"