Prosaptide TX14(A) peptide

Prosaptide TX14(A) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-TALIDNNATEEILY-OH, Alanine-2 is D configuration

H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH

14

95.57%

C₆₉H₁₁₀N₁₆O₂₆

1579.69

Synthetic

Powder

Prosaptide TX14(A) is derived from the active region of saposin C, itself derived from proteolytic processing of prosaposin, a 517-amino acid residue protein and neurotropic factor. Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1 with EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37. Prosaptide TX14(A) can protect primary astrocytes against oxidative stress, prolongs cell survival in both Schwann cells and oligodendrocytes and has anti-allodynic properties in a rat model of gp120-induced tactile allodynia.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Hiraiwa et al (1997) Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc Natl Acad Sci U S A. 94(9) 4778 PMID: 9114068
• Jolivalt et al (2008) Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. Eur J Pain. 12(1) 76 PMID: 17466547
• Meyer et al (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 110 9529 PMID: 23690594

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.