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  • PRO20 peptide

PRO20 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319167

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* Buy 1 get 1 free (?) What is TFA?

Special Price 186.90 USD

Availability: 5 working days
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Product Information

  • Product Name
    PRO20 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-LPTRTATFERIPLKKMPSVREI-OH
  • Sequence
    H-Leu-Pro-Thr-Arg-Thr-Ala-Thr-Phe-Glu-Arg-Ile-Pro-Leu-Lys-Lys-Met-Pro-Ser-Val-Arg-Glu-Ile-OH
  • Length (aa)
    22
  • Peptide Purity (HPLC)
    98.72%
  • Molecular Formula
    C116H199N33O31S
  • Molecular Weight
    2584.08
  • Source
    Synthetic
  • Form
    Powder
  • Description

    PRO20 is a 20-amino-acid peptide antagonist of the (pro)renin receptor (PRR). Its sequence corresponds to the first 20 amino acids of the (pro)renin prosegment. This peptide exhibits high specificity for both human and mouse PRR, functioning by competitively inhibiting the binding of (pro)renin to its receptor. In experimental models, subcutaneous administration of PRO20 has been shown to modulate hepatic lipid metabolism. Mechanistically, treatment with PRO20 is associated with the attenuation of diet-induced increases in the expression of key lipid synthesis regulators in the liver, including the transcription factor PPARγ and the enzyme glycerol-3-phosphate acyltransferase 3 (GPAT3). These molecular effects correlate with a reduction in hepatic triglyceride accumulation and lipid droplet formation.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Gayban AJB, Souza LAC, Cooper SG, Regalado E, Kleemann R, Feng Earley Y. (Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet-Induced Hepatic Steatosis. Biomolecules. 2023 Jan 10;13(1):142.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"