PRO20 peptide

PRO20 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-LPTRTATFERIPLKKMPSVREI-OH

H-Leu-Pro-Thr-Arg-Thr-Ala-Thr-Phe-Glu-Arg-Ile-Pro-Leu-Lys-Lys-Met-Pro-Ser-Val-Arg-Glu-Ile-OH

22

98.72%

C₁₁₆H₁₉₉N₃₃O₃₁S

2584.08

Synthetic

Powder

PRO20 is the PRR antagonist. PRO20 reduces HFD-induced lipid deposition in the liver as well as liver triglyceride content without significantly impacting body weight or glucose metabolism. PRO20 treatment reduced mRNA expression of the transcription factor PPARγ and its downstream target, Gpat3, encoding the lipogenesis pathway enzyme GPAT3, in HFD-fed mice.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Gayban AJB, Souza LAC, Cooper SG, Regalado E, Kleemann R, Feng Earley Y. (Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet-Induced Hepatic Steatosis. Biomolecules. 2023 Jan 10;13(1):142.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.