PPFLMLLKGSTR peptide

PPFLMLLKGSTR peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-PPFLMLLKGSTR-OH

H-Pro-Pro-Phe-Leu-Met-Leu-Leu-Lys-Gly-Ser-Thr-Arg-OH

12

95.32%

C₆₃H₁₀₆N₁₆O₁₅S

1359.67

Synthetic

Powder

PPFLMLLKGSTR is a novel motif identified within the LG3 domain of the human laminin-5 a3 chain. It has been found to be crucial for integrin a3h1 binding and cell adhesion. The PPFLMLLKGSTR peptide within the LG3 domain is capable of supporting integrin a3h1-dependent cell adhesion and spreading. Studies have shown that the Arg residue within the PPFLMLLKGSTR peptide is important for these activities.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Kim JM, Park WH, Min BM. The PPFLMLLKGSTR motif in globular domain 3 of the human laminin-5 alpha3 chain is crucial for integrin alpha3beta1 binding and cell adhesion. Exp Cell Res. 2005 Mar 10;304(1):317-27. doi: 10.1016/j.yexcr.2004.11.009. Epub 2004 Dec 8. PMID: 15707596.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.