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Recombinant PPCS protein (His tag)

Recombinant PPCS protein (His tag)

Cat.#: 548269

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Special Price 294.7 USD

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Product Information

  • Product Name
    Recombinant PPCS protein (His tag)
  • Documents
  • Description

    This product is a recombinant fragment of human Phosphopantothenate--cysteine ligase (PPC synthetase), encompassing amino acids 2-311. It represents a stable, soluble unit ideal for structural studies and biochemical assays, supporting research into coenzyme A biosynthesis.

    Phosphopantothenate--cysteine ligase, encoded by the PPCS gene in humans, catalyzes the second step in coenzyme A biosynthesis from vitamin B5. It conjugates cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, a critical reaction in cellular metabolism. The enzyme exhibits a preference for ATP over CTP as a cosubstrate, underscoring its role in energy-dependent cofactor production. This protein is essential for numerous metabolic pathways, making it a valuable target for biochemical and pharmacological investigations.

  • Protein name
    Phosphopantothenate--cysteine ligase
  • Uniprot ID
    Q9HAB8
  • Gene Name
    PPCS; COAB
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 2-311 aa (Q9HAB8) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 35.53 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 36 kDa band.
  • Purity
    >89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"