Cart 2
  • PPACK peptide

PPACK peptide

Not For Human Use, Lab Use Only.

Cat.#: 319813

Size:

* Buy 1 get 1 free (?) What is TFA?

Special Price 301.00 USD

Availability: 1-2 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    PPACK peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    fPR-{CMK}, f=D-Phe
  • Sequence
    D-Phe-Pro-Arg-chloromethylketone
  • Length (aa)
    3
  • Peptide Purity (HPLC)
    95%
  • Molecular Formula
    C21H31ClN6O3
  • Molecular Weight
    450.96
  • CAS No.
    71142-71-7
  • Source
    Synthetic
  • Form
    Powder
  • Description

    PPACK (D-Phe-Pro-Arg-Chloromethylketone) is a synthetic peptide that functions as a potent and selective thrombin inhibitor. It covalently binds to the active site of thrombin, effectively blocking its proteolytic activity. This peptide has been widely utilized in experimental studies to investigate coagulation mechanisms due to its high specificity and irreversible inhibition of thrombin.

    In biochemical assays, PPACK is often employed as an anticoagulant to prevent thrombin-mediated clotting and activation of coagulation cascades in blood samples. Its mechanism involves the formation of a stable complex with thrombin, thereby inhibiting fibrin formation and other thrombin-dependent processes. Studies comparing PPACK with traditional anticoagulants like citrate have shown varying effects on markers of coagulation and fibrinolysis, highlighting its role as a specialized tool for precise experimental conditions.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Rahr HB, Sørensen JV, Danielsen D. Markers of coagulation and fibrinolysis in blood drawn into citrate with and without D-Phe-Pro-Arg-Chloromethylketone (PPACK). Thromb Res. 1994 Mar 1;73(5):279-84. doi: 10.1016/0049-3848(94)90024-8. PMID: 8016814.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"